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For example, a study that looked at genetic differences in a group of 192 individuals who took 4 g/day of acetaminophen found that variants that decreased sulfation (specifically in the SULT1E1 gene) were more likely to have elevated liver enzymes
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In addition, GSH depletion and GSSG accumulation due to oxidative stress induce apoptosis by activating the SAPK/MAPK pathway [18]
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