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316 1175–1186 10.1124/jpet.105.094599 [DOI] [PubMed] [Google Scholar] Yang W

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Although induction of GLS1 or GLS2 leads to increased antioxidant capacity as a result of increases in reduced glutathione levels, the opposing effects of GLS1 and GLS2 in tumor progression suggest that the timing of and the flux through glutaminolysis can lead to tumor promotion or suppression