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Although the identity of the primary neural stem cell in the hippocampus and the lineage relationship between type 1 and type 2 cells is currently controversial (Tropepe, 2007), there is a consensus that the undifferentiated state and self-renewal of adult NPCs is controlled by the high-mobility-group DNA-binding protein Sox2 (Suh et al., 2007)
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Functional connectivity suggests functional connections between arbitrary neural regions, but it does not necessarily prove the direction of information transmission or a causal relationship with neural activity or cognitive function
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