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Semaglutide and tirzepatide work primarily through central nervous system mechanisms: appetite suppression in the hypothalamus, modification of food reward signaling in the brainstem, slowed gastric emptying that prolongs satiety
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[DOI] [PubMed] [Google Scholar] [195].Ahsan A, Ramanand SG, Bergin IL, Zhao L, Whitehead CE, Rehemtulla A, Ray D, Pratt WB, Lawrence TS, Nyati MK, Efficacy of an EGFR-specific peptide against EGFR-dependent cancer cell lines and tumor xenografts, Neoplasia, 16 (2014) 105β114