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For instance, for inflammatory pathways, blocking the expression of G6PD impaired pro-inflammatory cytokine expression and lipid accumulation in LPS-activated DCs ( de novo lipid synthesis, the loss of G6PD function also led to impaired NOS2 activity in Mφs activated by LPS (61) or by IFN-γ and infected by Trypanosoma cruzi (62)

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Ten-to-twelve-month-old beagle dogs weighing between 9.8 and 12.8 kg were purchased from YaDong Experimental Animal Research Centre, Nanjing, China