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It catalytically scavenges peroxides in the presence of reducing equivalents such as GSH, N-acetylcysteine (NAC), and dihydrolipoate (DHLA) [28]

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12–21 In light of the therapeutic benefits of ALA in the treatment of DPN, ALA has been further investigated for the treatment of various other neuropathies including chemotherapy-induced peripheral neuropathy (CIPN), entrapment neuropathies such as carpal tunnel syndrome (CTS), radicular nerve pain (sciatica), and burning mouth syndrome (BMS) with mixed results regarding its efficacy