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doi: 10.1111/j.1365-2125.2009.03522.x

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While the full picture is still being uncovered, researchers now know that inside the brain a cascade of events unfolds: nerve pathways become overactive, inflammatory processes are triggered, and key neuropeptides such as calcitonin gene-related peptide (CGRP), substance P, and neurokinin A amplify pain signals and contribute to blood vessel dilation